Antiviral phosphonate nucleotides

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United States of America Patent

PATENT NO 6444656
SERIAL NO

09534490

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: ##STR1## wherein n, X, Q U R1', R1, Z and R.sub.2 are defined here within. The compounds object of the present invention may be a single enantiomers or as mixtures of said enantiomers, the compounds may have a .alpha.D, .alpha.-L, .beta.-D, .beta.-L, R or S configuration at each chiral center or mixtures thereof. This invention also relates to pharmaceutical compositions containing them, alone or in combination with other therapeutic agents, and their use as antiviral agents, particularly against HIV and/or HBV infections in mammals.

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Patent Owner(s)

Patent OwnerAddress
BIOCHEM PHARMA INC2550 DANIEL JOHNSON BLVD LAVAL QUEBEC CANADA H7T 2L1 QUEBEC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nguyen-Ba, Nghe La Prairie, CA 35 974
Rej, Rabindra Montreal, CA 11 136

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