Phosphono-carboxylate compounds for treating amyloidosis
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United States of America Patent
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Aug 27, 2002
Grant Date -
Oct 4, 2001
app pub date -
May 17, 2001
filing date -
Apr 10, 1998
priority date (Note) -
Expired
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Abstract
Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
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