Method for preparing an R- or S-form of .alpha.-substituted heterocyclic carboxylic acid and a counter enantiomeric form of .alpha.-substituted heterocyclic carboxylic acid ester thereto using enzyme
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Aug 27, 2002
Grant Date -
Jan 17, 2002
app pub date -
May 30, 2001
filing date -
Jun 1, 2000
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
Disclosed is a method for preparing an R- or S-forms of .alpha.-substituted heterocyclic carboxylic acid (.alpha.-HCCA) and a counter enantiomeric form of .alpha.-substituted heterocyclic carboxylic acid ester thereto by use of an enzyme. A racemic .alpha.-HCCA is reacted with alcohol to give a racemic .alpha.-HCCA ester, which is then brought into contact with an enzyme with enantioselectivity, whereby either R-form or S-form of the racemate is hydrolyzed. Extraction with an organic solvent can obtain enantiomers of the .alpha.-HCCA ester. Thus, a certain enantiomeric form of .alpha.-HCCA and a counter enantiomeric form of .alpha.-HCCA ester thereto, respectively can be prepared with high optical purity at high yields as well as at low cost.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully