Trans cyclopentanyl purine analogs useful as immunosuppressants
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United States of America Patent
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Aug 20, 2002
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N/A
app pub date -
Nov 20, 1997
filing date -
Dec 6, 1991
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Abstract
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, Y.sub.3, Y.sub.5 Y.sub.7, Y.sub.9 are each nitrogen and Y.sub.8 is a CH group, R is a hydrogen, a C.sub.1-C.sub.7 alkyl acyl or aryl acyl, Q is NH.sub.2, halogen or hydrogen, Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
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