Alpha-substitution of unprotected .beta.-amino ester compounds
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United States of America Patent
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Aug 13, 2002
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N/A
app pub date -
Jan 26, 2000
filing date -
Dec 31, 1998
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Abstract
Methods for stereoselective substitution in which a (mono or un)-.alpha.-substituted unprotected .beta.-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
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