Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches
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United States of America Patent
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Aug 13, 2002
Grant Date -
Dec 27, 2001
app pub date -
Jul 17, 1998
filing date -
Jul 21, 1997
priority date (Note) -
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Abstract
Methods, kits, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition and an intranasal applicator and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention.
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