Vasopressin antagonist and diuretic combination

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United States of America Patent

PATENT NO 6420358
SERIAL NO

09669461

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Abstract

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This invention provides methods of increasing urine flow in humans while minimizing the loss of electrolytes or ions, the methods comprising administering to a human in need thereof a combination of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)-3-chlorophenyl]-5-fluoro-2-methylbenzamide (or a pharmaceutically acceptable salt thereof), also known as VPA-985, and one or more diuretic agents, as well as pharmaceutical compositions and kits or packages for such combinations.

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Patent Owner(s)

Patent OwnerAddress
CARDIOKINE BIOPHARMA LLC30 SOUTH 15TH STREET 15TH FLOOR PHILADELPHIA PA 19102

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ellis-Grosse, Evelyn Downingtown, PA 8 2
Orczyk, Gayle P Berwyn, PA 2 3

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