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Abstract

Ether and amide derivatives are disclosed, which are represented by the following formula (I) and its pharmaceutical acceptable salt, and which are useful for the treatment of diabetes. R.sub.1 --A--R.sub.2 (I) wherein ##STR1## ##STR2## (with the provisos that (i) when A is --O--, then n is 2 or 3 (ii) when ##STR3## then n is 1 or 2. R.sub.3 is OH--, CH.sub.3 SO.sub.2 NH--, CF.sub.3 SO.sub.2 NH--, CH.sub.3 SO.sub.2 NHCH.sub.2 --, CF.sub.3 SO.sub.2 NHCH.sub.2 --, HOOC--, CH.sub.3 OOC--, ##STR4## HOOC--CH.sub.2 SO.sub.2 NH--, CF.sub.3 --CH.sub.2 SO.sub.2 NH--, ##STR5## R.sub.8 --NHSO.sub.2 --, R.sub.8 --NHSO.sub.2 --CH.sub.2 --, HOOC--CH.sub.2 --O--, HSO.sub.3 N.dbd.CH--, or R.sub.9 --SO.sub.2 NHCO--; R.sub.4 is H, OH, O-alkyl or O--CH.sub.2 OCH.sub.3 ; R.sub.5 is H, halogen atom, --CH.sub.2 COOH or OH; R.sub.6 and R.sub.7 are hydrogen, t-butyl or pyrolidyl; R.sub.8 is hydrogen or lower alkyl; R.sub.9 is alkyl or thienyl; R.sub.10 is lower alkyl) or a pharmaceutically acceptable salt.

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First Claim