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Abstract

The invention relates to cinnamamide derivatives having the following formula ##STR1## wherein R.sup.1 represents a hydroxyl group, a C.sub.1-6 -alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R.sup.2 and R.sup.3 are same or different, each of which represents a hydrogen atom, a halogen atom or a C.sub.1-4 -alkyl group; R.sup.4 represents a hydrogen atom or a C.sub.1-6 -alkyl group; R.sup.5 represents a hydrogen atom, a C.sub.1-6 -alkyl group or an aryl group; R.sup.6 represents a hydrogen atom, a C.sub.1-6 -alkyl group, a cyano group or a C.sub.1-6 -alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: --C(R.sup.2)(R.sup.3)--W-- may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.

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First Claim