New arylglycinamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
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United States of America Patent
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Jul 2, 2002
Grant Date -
Jul 4, 2002
app pub date -
Oct 5, 2001
filing date -
Apr 14, 1995
priority date (Note) -
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Abstract
The invention relates to new arylglycinamide derivatives of general formula I 1 and the pharmaceutically acceptable salts thereof, wherein R.sup.1 and R.sup.2 together with the N to which they are bound form a ring of the formula 2 wherein p is 2 or 3 and X denotes oxygen, N(CH.sub.2).sub.nR.sup.6 or CR.sup.7R.sup.8, and R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
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