Polyamine analog-activated SSAT gene therapy
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United States of America Patent
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Jul 2, 2002
Grant Date -
N/A
app pub date -
Jun 29, 2000
filing date -
Jul 16, 1999
priority date (Note) -
Expired
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Abstract
The present invention provides a novel method to increase both the antitumor potency and the selectivity of DENSPM, a polyamine analog. The method comprises the steps increasing the amount of SSAT mRNA, and delivering a therapeutically sufficient dose of DENSPM which allows conversion of SSAT mRNA to enzyme activity, polyamine pool depletion and growth inhibition. The SSAT mRNA may be increased by conditionally induced overexpression of SSAT, or by modulating the transcriptional regulation of the endogenous SSAT gene.
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