Identification of broadly reactive DR restricted epitopes
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United States of America Patent
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Jul 2, 2002
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N/A
app pub date -
Jan 21, 1998
filing date -
Jan 23, 1997
priority date (Note) -
Expired
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Abstract
The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic residue in position 1 (Y, F, W, L, I, V, M) and a small, non charged residue in position 6 (S, T, C, A, P, V, I, L, M). In addition, allele-specific secondary effects and secondary anchors are defined, and these results were utilized to derive allele specific algorithms. By the combined use of such algorithms peptides capable of degenerate DR1, 4, 7 binding were identified.
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