Baccatin derivatives and a process for producing the same
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United States of America Patent
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Jun 25, 2002
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N/A
app pub date -
Feb 7, 2000
filing date -
Feb 16, 1999
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Abstract
The object of the invention is to develop baccatin derivatives useful for preparing taxoid compounds such as paclitaxel and a process for the producing the same. The invention provides baccatin derivatives represented by the general formula (I) as well as a process for producing baccatin derivatives represented by the general formula (I) above, which comprises allowing a baccatin represented by the general formula (II) to react with a .beta.-ketoester in the absence of a catalyst or in the presence of a tin compound or an amine base, preferably under reduced pressure.
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