Indeno [1,2-c] pyrazol-4-ones and their uses
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United States of America Patent
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Jun 18, 2002
Grant Date -
Oct 4, 2001
app pub date -
Dec 6, 2000
filing date -
Apr 21, 1998
priority date (Note) -
Expired
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Abstract
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
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