PAI-2 and T-PA as diagnostic markers of periodontal disease
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United States of America Patent
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Jun 18, 2002
Grant Date -
Jan 31, 2002
app pub date -
Jan 26, 1999
filing date -
Jan 26, 1998
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Abstract
The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and they also correlate with the severity of disease at different sites in the same patient.
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