Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
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United States of America Patent
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Jun 18, 2002
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N/A
app pub date -
Jun 3, 1999
filing date -
Mar 10, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
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