Methods of modulating immune coagulation
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United States of America Patent
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Jun 11, 2002
Grant Date -
N/A
app pub date -
Nov 15, 1999
filing date -
May 15, 1997
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Expired
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Abstract
Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.
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