Compound possessing potent thrombin receptor antagonist activity
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United States of America Patent
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Jun 4, 2002
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N/A
app pub date -
May 11, 2000
filing date -
May 11, 1999
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Abstract
The subject invention concerns eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol. This compound can be isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist and, furthermore, inhibits human platelet aggregation. Longer chain penasterol oligosaccharides were also isolated and characterized but these had weaker activity than eryloside F. The subject invention also concerns methods for inhibiting thrombin receptor activity and methods for inhibiting platelet aggregation through the administration of eryloside F, or a salt, derivative or analog thereof.
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