Process for producing erythropoietin containing no animal proteins
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United States of America Patent
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Jun 4, 2002
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N/A
app pub date -
Feb 13, 1998
filing date -
May 11, 1995
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Abstract
A process for producing erythropoietin which is free of foreign animal proteins except for the proteins of the host cell, wherein DNA coding for EPO is expressed in a eukaryotic host cell and the host cell is cultured in a medium free of natural mammalian proteins. The erythropoietin is chromatographically purified using dye affinity chromatography, chromatography on hydroxyapatite, reversed phase chromatography, and anion exchange chromatography. The resulting preparation contains less than 100 ppm of proteins derived from the host cell, and less than 10 pg of host cell DNA per 83 .mu.g erythropoietin.
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