Methods and compositions for impairing multiplication of HIV-1
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United States of America Patent
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Jun 4, 2002
Grant Date -
N/A
app pub date -
Apr 28, 2000
filing date -
Apr 28, 2000
priority date (Note) -
Expired
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Abstract
A composition which elicits antibodies to multiple known variants of Tat protein of HIV-1 of both the B and non-B clades contains the peptide R1-Asp-Pro-Asn-Leu-Asp-Pro-Trp-Asn-R2 SEQ ID NO: 23, and preferably an additional at least two variants of a peptide or polypeptide of the formula: R1-Asp-Pro-Y.sub.7 -Leu-Glu-Pro-Trp-Z.sub.12 -R2 SEQ ID NO: 8. In this composition, at least one of the two variants contains Arg at Y.sub.7 and Lys at Z.sub.12, and in at least a second of the two variants Y.sub.7 is Asn and Z.sub.12 is Asn. Vaccinal and pharmaceutical compositions can contain one or more such peptides associated with carrier proteins, associated in multiple antigenic peptides, or as part of recombinant proteins. Diagnostic compositions and uses are described for assessing the immune status of vaccinated patients.
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