Method for purification of antithrombin III using an anion exchanger

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United States of America Patent

PATENT NO 6395880
SERIAL NO

09509052

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Abstract

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A method of purifying antithrombin III (AT III) from a starting material containing an AT III/heparin complex or an AT III/heparinoid complex is disclosed. First, the method comprises adsorbing the AT III/heparin complex or the AT III/heparinoid complex on an anion exchanger material. Second, the method involves separating the AT III from the adsorbed AT III/heparin complex or an AT III/heparinoid complex by elution with a buffer having a pH ranging from 8.5 to 10.5 and a conductivity between 10 and 60 mS.

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Patent Owner(s)

Patent OwnerAddress
BAXTER AKTIENGESELLSCHAFTINDUSTRISTRASSE 67 A-1221 VIENNA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hetzl, Ernst Vienna, AT 4 24
Linnau, Yendra Vienna, AT 43 1473
Matthiessen, H Peter Vienna, AT 2 21
Neppl, Silvia Vienna, AT 1 3
Schonhofer, Wolfgang St. Polten, AT 3 9
Schwarz, Hans-Peter Vienna, AT 143 1170

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