Plasmids that encode green fluorescent protein
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United States of America Patent
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May 21, 2002
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N/A
app pub date -
Mar 1, 1999
filing date -
May 31, 1996
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Abstract
Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that encodes a reporter molecule and a second p53 binding polynucleotide sequence that is operably linked to the first polynucleotide sequence such that binding of p53 to the second polynucleotide sequence causes the expression of the reporter molecule which can be detected or quantified.
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