Composition and method of preparing microparticles of water-insoluble substances
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United States of America Patent
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May 14, 2002
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N/A
app pub date -
Jan 4, 2000
filing date -
Mar 30, 1998
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Abstract
Compositions and procedures that yield sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds are prepared using combinations of natural or synthetic phospholipids, a charged surface modifier such as a highly purified charged phospholipid and a block copolymer coated or adhered onto the surfaces of the water insoluble-compound particles. The combination of charged surface modifier and block copolymer allows the formation and stabilization of the sub-micron and micron size compound particles--stabilized by the charged phospholipid to provide electrostatic stabilization and the block copolymer to provide steric stabilization--and therefore prevents these particles from particle growth, aggregation or flocculation.
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