N-benzenesulfonyl-L-proline compounds, preparation method and method for using the compounds in therapy
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United States of America Patent
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May 7, 2002
Grant Date -
N/A
app pub date -
Dec 27, 1999
filing date -
Jun 27, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to compounds selected from the group consisting of: (i) the compounds of the formula ##STR1## in which X is a halogen atom, A is a group --NH--(CH.sub.2).sub.n --NH--CO--, --NH--CH.sub.2 -- or ##STR2## Q is a group ##STR3## R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.5 1-oxoalkyl, R.sub.2 is H or OH and n is 2, 3 or 4; and (ii) their addition salts. It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.
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