Cell-specific active compounds regulated by the cell cycle
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United States of America Patent
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May 7, 2002
Issued Date -
N/A
app pub date -
Apr 25, 1997
filing date -
Aug 26, 1994
priority date (Note) -
Expired
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Abstract
A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell. Depending on the choice of activator sequence and active substance, the following can be treated by administering the DNA sequence: defective formation of blood cells; autoimmune diseases and allergies and, in addition, rejection reactions against transplanted organs; chronic arthritis; viral and parasitic infections and, in addition, prophylaxis of viral, bacterial and parasitic infections; and leukemias.
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