Mammalian cell lines expressing bovine adenovirus functions
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United States of America Patent
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Apr 30, 2002
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app pub date -
Nov 5, 1999
filing date -
Dec 9, 1993
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Abstract
The present invention provides novel recombinant mammalian cell lines expressing bovine adenovirus functions. In one embodiment, mammalian cell lines stably transformed with bovine adenovirus E1 sequences express bovine adenovirus E1 gene products and are useful for the replication of bovine adenovirus vectors having deletions and/or insertions in the E1 region. Such vector/cell line combinations are useful for synthesis of recombinant polypeptides, preparation of subunit vaccines, and in gene therapy.
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