Chip-based isothermal amplification devices and methods
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United States of America Patent
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Apr 30, 2002
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N/A
app pub date -
Nov 19, 1997
filing date -
Nov 20, 1996
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Abstract
Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.
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