Solid-phase technology for the preparation of amides
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United States of America Patent
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Apr 16, 2002
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N/A
app pub date -
May 20, 1999
filing date -
Oct 22, 1996
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Expired
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Abstract
Method for preparing a combinatorial chemistry library of compounds of the formula R1--C(.dbd.O)--NH--R2, wherein R1 and R2 are as defined in the specification, which comprises acylating a combinatorial chemistry intermediate of the formula 1A ##STR1## wherein Y1, Y2, X, n, R1 and R2 are as defined in the specification to produce a compound of the formula ##STR2## wherein Y1, R1, R2 and X are as defined in the specification, followed by acidolytic cleavage of the resin bound linker to release the compound of the formula R1--C(.dbd.O)--NH--R2.
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