Pharmaceutical compositions containing antibody-enzyme conjugates in combination with prodrugs
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United States of America Patent
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Apr 16, 2002
Grant Date -
N/A
app pub date -
May 22, 2000
filing date -
Jun 11, 1997
priority date (Note) -
Expired
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Abstract
Prodrugs which can be activated by enzymes, are formulated for sequential administration, with enzyme conjugates. Either or each component comprises a polymeric carrier which allows it to be directed preferentially to the target tissue. A new polymer-prodrug conjugate is cleavable by cathepsin-B or othe invention is of particular utility for targeting solid tumours.
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