Process for the preparation of cephalosporins using acremonium chrysogenum
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United States of America Patent
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Apr 9, 2002
Grant Date -
N/A
app pub date -
Jan 15, 1999
filing date -
Jul 16, 1996
priority date (Note) -
Expired
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Abstract
An improved process for production of an N-acylated cephalosporin is described. The process utilizes an Acremonium strain which has been modified to express an acyl transferase of a filamentous fungus and is selected for production of the N-acylated cephalosporin at a level which is equal to or higher than the production of the corresponding .alpha.-aminoadipyl-7-cephalosporins in the strain.
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