Guanosine-rich oligonucleotide integrase inhibitors
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United States of America Patent
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Mar 12, 2002
Grant Date -
N/A
app pub date -
Oct 28, 1999
filing date -
Apr 23, 1993
priority date (Note) -
Expired
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Abstract
A method and compositions for treating viral infection (IV) vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
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