Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
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United States of America Patent
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Mar 5, 2002
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N/A
app pub date -
Feb 8, 2000
filing date -
Aug 3, 1999
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Abstract
Derivatives of camptothecin as represented by the general formula: ##STR1## are described, wherein when R.sub.1 is H, R. is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group or an amino group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.1 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Liposomal prodrugs including these specific derivatives of camptothecin restrained by a liposomal delivery system are also described. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
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