2-Substituted-4-substituted-1,3-dioxolanes and use thereof
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United States of America Patent
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Feb 26, 2002
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app pub date -
Sep 30, 1998
filing date -
Apr 11, 1988
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Abstract
Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include: cis-2-acetoxymethyl-4-(thymin-1'-yl)-1,3,-dioxolane, cis-2-hydroxymethyl-4-(thymin-1'-yl)-1,3-dioxolane, cis-2-benzoyloxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane, and cis-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane. These compounds can be in the form of their racemates or their separate enantiomers.
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