Interaction between cyclin D1 and steroid receptor coactivators and users thereof in assays
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United States of America Patent
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Feb 26, 2002
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Apr 30, 1999
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Feb 12, 1998
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Abstract
The present invention relates to the finding that cyclin D1 interacts in a ligand-independent fashion with coactivators of the SRC-1 family. The direct interaction of cyclin D1 enhances estrogen receptor (ER) mediated transcription and provides a novel target for the development of assays for substances which modulate the cell cycle. The invention provides assay methods for the prevention of growth of tumours, for assays for compounds useful in the prevention of tumours and compounds obtainable by such assays.
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