Sulfonamide compounds and medicinal use thereof

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United States of America Patent

PATENT NO 6348474
SERIAL NO

09446110

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Abstract

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A sulfonamide compound of the formula (I): R.sup.1 --SO.sub.2 NHCO--A--R.sup.2 (I) wherein R.sup.1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R.sup.2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

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Patent Owner(s)

Patent OwnerAddress
MGI GP INC5775 WEST OLD SHAKOPEE ROAD SUITE 100 BLOOMINGTON MN 55437

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abe, Yoshito Tsukuba, JP 35 655
Hamashima, Hitoshi Kyoto, JP 15 245
Hiramura, Takahiro Arai, JP 30 302
Imoto, Takafumi Arai, JP 16 276
Kayakiri, Hiroshi Suita, JP 47 671
Mizutani, Tsuyoshi Tsukuba, JP 22 312
Nishikawa, Masahiro Arai, JP 80 543
Oku, Teruo Takatsuki, JP 85 1191
Onomura, Osamu Nagasaki, JP 11 150
Sawada, Hitoshi Tsukuba, JP 26 539
Yamasaki, Noritsugu Himeji, JP 30 303

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