Cyanoguanidines as cell proliferation inhibitors

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United States of America Patent

PATENT NO 6346541
SERIAL NO

09424632

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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##STR1## The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R.sub.1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C.sub.1 -C.sub.4 alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C.sub.4 -C.sub.20 divalent hydrocarbon radical which can be straight, branched, cyclic, saturated or unsaturated and X stands for carbonyl, carbonylamino, aminocarbonyl, oxycarbonyloxy, oxycarbonyl, carbonyloxy, aminocarbonyloxy, aminothiocarbonyloxy, oxycarbonylamino or oxythiocarbonylamino and Y stands for benzylene or phenylene and R.sub.2 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxyalkyl or alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulfamoyl, nitro, amino, carboxy, alkoxycarbonyl or benzyloxy; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.

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Patent Owner(s)

Patent OwnerAddress
LEO PHARMACEUTICAL PRODUCTS LTD A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIES ELSKAB)INDUSTRIPARKEN 55 DK-2750 BALLERUP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunneche, Charlotte Schou Istanbul, TR 5 2

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  • 2 Citation Count
  • A61K Class
  • 9.90 % this patent is cited more than
  • 23 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges344181063626215310053322118113601 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +010020030040050060070080090010001100120013001400150016001700180019002000

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