Microorganisms producing 5-aminolevulinic acid and processes for producing 5-aminolevulinic acid by using the same
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United States of America Patent
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Jan 29, 2002
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Feb 28, 2000
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May 27, 1997
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Abstract
Microorganisms producing 5-aminolevulinic acid which show a 5-aminolevulinic acid synthetase activity of 2 to 7 (nmol/min/mg protein) under aerobic culture conditions with a dissolved oxygen concentration of 0.70 to 6.60 ppm; a process for producing 5-aminolevulinic acid characterized by culturing one or more microorganisms and harvesting 5-aminolevulinic acid from the obtained culture; a process for producing 5-aminolevulinic acid characterized by culturing 5-aminolevulinic acid-producing microorganisms in a medium containing 5 to 500 .mu.M of iron components; and a method for culturing 5-aminolevulinic acid-producing microorganisms.
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