Apparatus and method for performing microfluidic manipulations for chemical analysis
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United States of America Patent
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Jan 29, 2002
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app pub date -
Apr 27, 1999
filing date -
Aug 1, 1994
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Abstract
A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.
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