Modulation of apoptosis with bid
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United States of America Patent
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Dec 4, 2001
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app pub date -
Aug 19, 1998
filing date -
Aug 19, 1998
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Abstract
A novel p15 BID polypeptide having cell death agonist activity is disclosed. The p15 BID polypeptide is produced by caspase-cleavage of BID in cells undergoing cell death mediated by TNF or FAS receptors. The p15 BID is useful in methods for modulating death of a target cell which comprise treating the cell with p15 BID. Methods for inhibiting cell death are also described which involve treating a target cell with a mutant p15 BID lacking cell death agonist activity.
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