Benzopyranyl guanidine derivatives, process for preparation thereof, and pharmaceutical compositions containing them
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United States of America Patent
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Nov 27, 2001
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N/A
app pub date -
Oct 20, 2000
filing date -
Oct 21, 1999
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Abstract
The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. ##STR1## Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n and * are each defined in specification.
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