Peptide agonists of bradykinin B2 receptor
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United States of America Patent
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Nov 13, 2001
Grant Date -
N/A
app pub date -
Jun 4, 1999
filing date -
Dec 4, 1996
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Expired
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Abstract
The invention concerns a pseudopeptide compounds selected among the set constituted by: (i) the compounds of formula (I): ##STR1## in which: A.sub.1 represents a single bond, D-Arg or L-Lys; A.sub.2 represents L-Pro or trans-4-hydroxy-L-Pro (4Hyp); A.sub.3 represents L-Phe or L-thienylalanine (Thi); Y represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; X represents a sulphur or oxygen atom; and, (ii) their additive salts. The invention also concerns the preparation and use of this compound and its additive salts in therapy.
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