Cephalosporins
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United States of America Patent
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-
Nov 6, 2001
Issued Date -
N/A
app pub date -
Jul 21, 1997
filing date -
Dec 12, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A compound having the formula selected from the group consisting of ##STR1## wherein either R.sub.3p and R.sub.4p are identical and selected from the group consisting of --OH, protected --OH and acyloxy of 1 to 8 carbon atoms, R.sub.2p is selected from the group consisting of --CN, --F, Br and I and R.sub.1p and R.sub.5p are hydrogen or R.sub.5p is --F and R.sub.1p and R.sub.2p are hydrogen or R.sub.1p and R.sub.2p are F and R.sub.5p is hydrogen, or R.sub.4p and R.sub.5p are identical and selected from the group consisting of --OH, protected --OH and acyloxy of 1 to 8 carbon atoms, R.sub.3p is selected from the group consisting of F and --CN and R.sub.1p and R.sub.2p are hydrogen, R.sub.8 is hydrogen or an amine protective group and R.sub.10 is the remainder in which the hydroxy or amino are protected ##STR2## wherein R'.sub.1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, --CN, carboxy and alkoxy carbonyl of 1 to 4 carbon atoms.
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