Quinolone carboxylic acid derivatives
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United States of America Patent
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Nov 6, 2001
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N/A
app pub date -
Dec 23, 1999
filing date -
Jun 26, 1997
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Abstract
The present invention relates to quinolonecarboxylic acid derivatives having more excellent and broad antibacterial activities than the existing quinolone-series antibiotics. More specifically, it pertains to novel quinolonecarboxylic acid derivatives represented by following formula 1, which have a derivative of 7-[8-(alkoxyimino)-2,6-diazaspiro[3.4]oct-6-yl] as a substituent, and pharmaceutically acceptable salts and isomers thereof: ##STR1## Wherein, A is C--H, C--F, C--Cl, C--O--CH.sub.3 or N; Y is H or amino; R.sub.1 is cyclopropyl or 2,4-difluorophenyl; R.sub.2 is C.sub.1-4 alkyl; and R.sub.3 is H or C.sub.1-4 alkyl.
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