Base-catalyzed synthesis of 1-aryl-4-(aryl ethyl)piperazines from aromatic olefins and 1-arylpiperazines
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United States of America Patent
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Nov 6, 2001
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N/A
app pub date -
Jul 13, 2000
filing date -
Jan 17, 1998
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Expired
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Abstract
A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I) ##STR1## by reacting a 1-arylpiperazine of the formula (II) ##STR2## with an aromatic olefin of the formula (III) Ar'CR.sup.1.dbd.CHR.sup.2 (III) in an inert solvent in the presence of at least one basic catalyst, where in the formulae (I) to (III) Ar and Ar' independently of one another are an aryl radical, selected from the group of the fused and unfused C.sub.6 -C.sub.22 -aromatics and the fused or unfused C.sub.5 -C.sub.22 -heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring; and R.sub.1 and R.sub.2 independently of one another are a hydrogen atom, a C.sub.1 -C.sub.8 -alkyl radical or an aryl radical Ar.
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