Pharmaceutical composition comprising cyclosporin solid-state microemulsion
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United States of America Patent
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Oct 23, 2001
Grant Date -
N/A
app pub date -
Jun 1, 2000
filing date -
Dec 2, 1997
priority date (Note) -
Expired
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Abstract
A pharmaceutical composition comprising a cyclosporin solid-state microemulsion is disclosed. In a preferred embodiment, the composition comprises a cyclosporin microemulsion dispersed in an enteric carrier. The composition does not dissolve in external phases such as artificial gastric fluid, but dissolves rapidly in artificial intestinal fluid, whereby it releases the cyclosporin microemulsion, providing rapid delivery of cyclosporin. The composition effectively maintains a therapeutic blood concentration of cyclosporin with once a day dosing, providing for convenience of administration and avoiding adverse effects induced by increasing peak blood cyclosporin concentrations associated with conventional cyclosporin formulations.
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