Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins
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United States of America Patent
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Oct 23, 2001
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N/A
app pub date -
Mar 21, 1997
filing date -
Mar 21, 1996
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Expired
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Abstract
The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.
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