Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
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United States of America Patent
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Oct 16, 2001
Grant Date -
N/A
app pub date -
Apr 12, 1999
filing date -
Apr 13, 1998
priority date (Note) -
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Abstract
A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments twisted into a yarn or woven into a mesh, and can be in the form of a cylinder. When implanting the device, the semi-permeable membrane is preferably immunolsolatory, and the cells or tissue may produce a biologically active molecule to provide therapy. To enhance cell or tissue adhesion, the matrix is coated with extracellular matrix molecules or treated to provide a surface charge. The device can be made by inserting the matrix into a capsule formed of the semi-permeable membrane, distributing the cells or tissue on the matrix through an opening of the capsule, and sealing the opening of the capsule.
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