1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
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United States of America Patent
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Sep 25, 2001
Grant Date -
N/A
app pub date -
Oct 27, 2000
filing date -
Apr 28, 1998
priority date (Note) -
Expired
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Abstract
Compound of the formula (I): ##STR1## wherein Ar is a group of the following formula (Ar-1) or (Ar-2): ##STR2## A is a group of the formula: --Z--N(Q.sup.1)(Q.sup.2), --CO--R.sup.7 or --(CH.sub.2)p--CH(R.sup.8)--COR.sup.9, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, a pharmaceutical composition containing the same, and intermediates therefor. The compounds of the present invention show a potent affinity for 5-HT.sub.4 receptors, and they are useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent.
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