Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
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United States of America Patent
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Sep 11, 2001
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app pub date -
May 27, 1998
filing date -
May 27, 1998
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Abstract
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T).sub.x A--B--D--E--G wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR1## the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents ##STR2## and with the proviso that when G is ##STR3## each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof.
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