Anti-viral guanosine-rich tetrad forming oligonucleotides
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United States of America Patent
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Sep 11, 2001
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N/A
app pub date -
Feb 3, 1998
filing date -
Apr 23, 1993
priority date (Note) -
Expired
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Abstract
Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.
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